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Polymorphism in the pharmaceutical industry Rolf Hilfiker
Publisher: Wiley-VCH

The knowledge of the effects of polymorphisms of genes for the enzymes is applied in drug discovery and development as well as in clinical use of drugs. It is now realized that many drug-drug interactions can be explained by alterations in the metabolic enzymes that are present in the liver and other extra-hepatic tissues. It is also responsible for the breakdown of many low molecular weight toxins and carcinogens, many of which are used in manufacturing and dry cleaning industry, including benzene, styrene, acetone, vinyl chloride and N-nitrosamines. To date, more than 70 polymorphisms of CYP2D6 have been catalogued. Of Health and published in Gut. GlaxoSmithKline - one of the world's leading research-based pharmaceutical and healthcare companies - is committed to improving the quality of human life by enabling people to do more, feel better Read more. Screening for polymorphs is crucial for drug research and development, since the crystal form of the active pharmaceutical ingredient (API) directly correlates with its pharmacokinetic properties. All you want to know about Drugs, live, by DR ANTHONY MELVIN CRASTO, Worlddrugtracker, Helping millions, million hits on google, pushing boundaries, one lakh connections worldwide, my soul in action for you .. Cost-effective methods for genotyping are being developed and it would For the pharmaceutical companies, segmentation of the market may not leave room for conventional blockbusters but smaller and exclusive markets for personalized medicines would be profitable. A letter on understanding triphasic HCV decline during treatment in the era of IL28B polymorphisms and direct acting antiviral agents via mathematical modeling, published in the Journal of Hepatology.